Search results for "cD [Galaxies]"

Novel σ1 antagonists designed for tumor therapy: Structure – activity relationships of aminoethyl substituted cyclohexanes

2021

Abstract Depending on the substitution pattern and stereochemistry, 1,3-dioxanes 1 with an aminoethyl moiety in 4-position represent potent σ1 receptor antagonists. In order to increase the stability, a cyclohexane ring first replaced the acetalic 1, 3-dioxane ring of 1. A large set of aminoethyl substituted cyclohexane derivatives was prepared in a six-step synthesis. All enantiomers and diastereomers were separated by chiral HPLC at the stage of the primary alcohol 7, and their absolute configuration was determined by CD spectroscopy. Neither the relative nor the absolute configuration had a large impact on the σ1 affinity. The highest σ1 affinity was found for cis-configured benzylamines…

Measurement of the azimuthal ordering of charged hadrons with the ATLAS detector

2012

This paper presents a study of the possible ordering of charged hadrons in the azimuthal angle relative to the beam axis in high-energy proton-proton collisions at the Large Hadron Collider (LHC). A spectral analysis of correlations between longitudinal and transverse components of the momentum of the charged hadrons, driven by the search for phenomena related to the structure of the QCD field, is performed. Data were recorded with the ATLAS detector at center-of-mass energies of √s=900  GeV and √s=7  TeV. The correlations measured in a kinematic region dominated by low-pT particles are not well described by conventional models of hadron production. The measured spectra show features consis…

The frame-shift mutation of the NOD2/CARD15 gene is significantly increased in ulcerative colitis: An ∗IG-IBD study

2004

Heavy quarkonium: progress, puzzles, and opportunities

2011

A golden age for heavy quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the $B$-factories and CLEO-c flo…

High-energy evolution to three loops

2018

The Balitsky-Kovchegov equation describes the high-energy growth of gauge theory scattering amplitudes as well as nonlinear saturation effects which stop it. We obtain the three-loop corrections to this equation in planar $\mathcal{N}=4$ super Yang-Mills theory. Our method exploits a recently established equivalence with the physics of soft wide-angle radiation, so-called non-global logarithms, and thus yields at the same time the three-loop evolution equation for non-global logarithms. As a by-product of our analysis, we develop a Lorentz-covariant method to subtract infrared and collinear divergences in cross-section calculations in the planar limit. We compare our result in the linear re…

QCD sum rule determination of the charm-quark mass

2011

QCD sum rules involving mixed inverse moment integration kernels are used in order to determine the running charm-quark mass in the $\bar{MS}$ scheme. Both the high and the low energy expansion of the vector current correlator are involved in this determination. The optimal integration kernel turns out to be of the form $p(s) = 1 - (s_0/s)^2$, where $s_0$ is the onset of perturbative QCD. This kernel enhances the contribution of the well known narrow resonances, and reduces the impact of the data in the range $s \simeq 20 - 25 GeV^2$. This feature leads to a substantial reduction in the sensitivity of the results to changes in $s_0$, as well as to a much reduced impact of the experimental u…

Quark–hadron duality: Pinched kernel approach

2016

Hadronic spectral functions measured by the ALEPH collaboration in the vector and axial-vector channels are used to study potential quark-hadron duality violations (DV). This is done entirely in the framework of pinched kernel finite energy sum rules (FESR), i.e. in a model independent fashion. The kinematical range of the ALEPH data is effectively extended up to $s = 10\; {\mbox{GeV}^2}$ by using an appropriate kernel, and assuming that in this region the spectral functions are given by perturbative QCD. Support for this assumption is obtained by using $e^+ e^-$ annihilation data in the vector channel. Results in both channels show a good saturation of the pinched FESR, without further nee…

Patient Alert to detect ICD lead failure: efficacy, limitations, and implications for future algorithms.

2006

Aims An algorithm that alerts implantable cardioverter-defibrillator (ICD) patients, in case of abnormal lead impedance (Patient Alert™, Medtronic), may help to recognize lead dysfunction. We aimed to determine the utility of Patient Alert for ICD lead-failure detection in a prospective study. Methods and results Three hundred and sixty ICD patients were followed for 22±14 months. Patient Alert was active for pacing impedance 2000–3000 Ω, and high-voltage conductor impedance 200 Ω. Ten alert events and a total of 29 severe system complications occurred. Patient Alert detected three of 10 ICD lead failures, with a positive predictive value (PPV) of 77.8% for any severe system complication. R…

ICD Implantation in infants and small children: the extracardiac technique.

2007

There is no clear methodology for implantation of an internal cardioverter-defibrillator (ICD) in infants and small children. The aim of this study was to assess efficacy and safety of an extracardiac ICD implantation technique in pediatric patients.An extracardiac ICD system was implanted in eight patients (age: 0.3-8 years; body weight: 4-29 kg). Under fluoroscopic guidance a defibrillator lead was tunneled subcutaneously starting from the anterior axillar line along the course of the 6th rib until almost reaching the vertebral column. After a partial inferior sternotomy, bipolar steroid-eluting sensing and pacing leads were sutured to the atrial wall (n = 2) and to the anterior wall of t…

Factors associated with mild cognitive impairment in a population-based cohort

2017

Il lavoro non prevede abstract